On the influence of polyethyleneimine modification in nanogel-driven drug delivery

Nanogels are nanometric three-dimensional structures formed by chemically or physically cross-linked polymers with hydrophilic amphiphilic macromolecular chains. Biocompatibility, biodegradability, water solubility and nontoxicity the properties of these colloids that make them very interesting to be used in biomedical fields especially drug delivery applications. Several strategies have been proposed for preparation nanogels capable uptake release a great variety compounds; however, encapsulation hydrophobic compounds inside structure has proven difficult. The goal this work is study how performances can influenced chemical modification linear polyethyleneimine (PEI) if ability load drugs from improved way. In vitro tests were performed using rhodamine B pyrene as model mimetics, respectively. maintenance an efficient was confirmed (cumulative up 80 % 120 h) like our previous formulations, but optimal loading efficiency, time-controlled release, emerged also molecules, due introduction modifications nanogel framework.